Indications for use of the drug PAXIL®

Depression of all types, including reactive and severe depression, as well as depression, accompanied by anxiety.

In the treatment of depressive disorders, paroxetine is about as effective as tricyclic antidepressants. paroxetine cheap online There is evidence that paroxetine may give good results in patients in whom standard antidepressant therapy has been found to be ineffective..

Taking paroxetine in the morning does not adversely affect the quality and duration of sleep. In addition, as the effects of paroxetine are manifested, sleep may improve..

When using short-acting sleeping pills in combination with antidepressants, additional side effects did not occur. Paroxetine effectively reduces symptoms of depression and suicidal thoughts in the first few weeks of therapy.

The results of studies in which patients took paroxetine for up to 1 year showed that the drug effectively prevents relapse of depression.

Paroxetine is effective in the treatment of obsessive-compulsive disorder (OCD), including and as a means of supportive and preventive therapy. In addition, paroxetine effectively prevented OCD relapses..

Paroxetine is effective in the treatment of panic disorder with agoraphobia and without it, including as a means of supportive and preventive therapy. In the treatment of panic disorder, the combination of paroxetine and cognitive-behavioral therapy was found to be significantly more effective than the isolated use of cognitive-behavioral therapy.

In addition, paroxetine effectively prevented recurrence of panic disorder..

Paroxetine is an effective treatment for social phobia, including and as a long-term supportive and preventive therapy.

Generalized Anxiety Disorder

Paroxetine is effective in generalized anxiety disorder, including and as a long-term supportive and preventive therapy. Paroxetine also effectively prevents relapse in this disorder..

Post-traumatic stress disorder

Paroxetine is effective in the treatment of post-traumatic stress disorder.

Short description

Paroxetine is a drug of the antidepressant group. Known since the late 1980s. Currently, it is widely used for depression of all types (atypical, seasonal, psychotic, postpartum, dysthymia, etc.), obsessive states neurosis, episodic paroxysmal anxiety (including associated with a fear of open space), social and generalized anxiety disorders, post-traumatic stress disorder, premenstrual dysphoric disorder, chronic headaches. The antidepressant effect of the drug determines its ability to selectively suppress the capture of serotonin by brain neurons - the so-called “Hormone of good mood” or “hormone of happiness” (in terms of the severity of this property, paroxetine is in the lead among all antidepressants known today). The drug is well absorbed in the gastrointestinal tract, partially undergoing the effect of the first passage through the liver with the formation of pharmacologically inert metabolites. A stable concentration of the active substance in the blood is achieved after 4-14 days of regular pharmacotherapy. The half-life of the drug is 21 hours, which allows you to limit yourself to a single dose of the drug per day (and this, in turn, increases compliance, i.e. the patient’s commitment to treatment). The pharmacokinetic characteristics of paroxetine vary depending on the age of the patients. The elimination rate in people suffering from liver and kidney diseases is reduced.

The drug has a favorable safety profile and, subject to the recommended dosage instructions, rarely causes side effects. Paroxetine does not suppress psychomotor processes and does not enhance the inhibitory effect on the psychomotor of ethanol-containing products. According to a study of behavioral reactions and an encephalogram, the drug exhibits a weak activating effect with a slight excess of the recommended doses. A significant change in blood pressure, heart rate and EEG does not occur. Paroxetine is contraindicated in case of individual intolerance to components, unstable epilepsy, during pregnancy and breastfeeding, when taking monoamine oxidase inhibitors (and for two weeks after the end of their intake). In pediatric practice, the drug is not used. The daily dose is 1 tablet. The optimal reception time is in the morning, during breakfast. Dose selection is carried out individually with the possibility of further adjustment after two to three weeks from the start of pharmacotherapy. The presence in the gastrointestinal tract of food contents and the administration of drugs that reduce the acidity of the stomach do not affect the pharmacokinetic characteristics of paroxetine. During drug therapy, it is recommended to refrain from drinking alcohol. Despite the fact that the drug does not affect psychomotor and cognitive functions, caution should be exercised during treatment when engaging in activities that require increased attention and speed of reaction, including driving a car.

Special instructions for taking Paroxetine

In order to avoid the development of malignant antipsychotic syndrome, Paroxetine should be prescribed with caution to patients taking antipsychotics. Paroxetine treatment is prescribed 2 weeks after discontinuation of MAO inhibitors. In elderly patients, while taking Paroxetine, hyponatremia is possible. In some cases, dose adjustment of simultaneously used insulin and / or oral hypoglycemic drugs is required.

With the development of seizures, treatment with Paroxetine is discontinued. At the first signs of mania, Paroxetine therapy should be discontinued. During the first few weeks of Paroxetine therapy, the patient's condition should be carefully monitored in connection with possible suicidal attempts. During therapy with Paroxetine, one should refrain from taking alcohol in connection with an increase in its toxic effect..

Pediatric Use

The use of Paroxetine in children is not recommended, since its safety and effectiveness in this group of patients have not been established.

Influence on the ability to drive vehicles and control mechanisms

Despite the fact that paroxetine does not impair cognitive and psychomotor functions, patients should refrain or exercise extreme caution when driving and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.